Viper Venom Botox: The Molecular Origin and Evolution of the Waglerin Peptides Used in Anti-Wrinkle Skin Cream.
Identifieur interne : 000066 ( Main/Exploration ); précédent : 000065; suivant : 000067Viper Venom Botox: The Molecular Origin and Evolution of the Waglerin Peptides Used in Anti-Wrinkle Skin Cream.
Auteurs : Jordan Debono [Australie] ; Bing Xie [République populaire de Chine] ; Aude Violette [Belgique] ; Rudy Fourmy [Belgique] ; Marc Jaeger [France] ; Bryan G. Fry [Australie]Source :
- Journal of molecular evolution [ 1432-1432 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Crème pour la peau, Données de séquences moléculaires, Peptides (), Phylogénie, Séquence d'acides aminés (génétique), Venins de crotalidé (génétique), Venins de crotalidé (toxicité), Venins de crotalidé (usage thérapeutique), Venins de vipère (toxicité), Venins de vipère (usage thérapeutique), Évolution biologique, Évolution moléculaire.
- MESH :
- génétique : Séquence d'acides aminés, Venins de crotalidé.
- toxicité : Venins de crotalidé, Venins de vipère.
- usage thérapeutique : Venins de crotalidé, Venins de vipère.
- Animaux, Crème pour la peau, Données de séquences moléculaires, Peptides, Phylogénie, Évolution biologique, Évolution moléculaire.
English descriptors
- KwdEn :
- Amino Acid Sequence (genetics), Animals, Biological Evolution, Crotalid Venoms (genetics), Crotalid Venoms (therapeutic use), Crotalid Venoms (toxicity), Evolution, Molecular, Molecular Sequence Data, Peptides (chemistry), Phylogeny, Skin Cream, Viper Venoms (therapeutic use), Viper Venoms (toxicity).
- MESH :
- chemical , chemistry : Peptides.
- chemical , genetics : Crotalid Venoms.
- genetics : Amino Acid Sequence.
- chemical , therapeutic use : Crotalid Venoms, Viper Venoms.
- chemical , toxicity : Crotalid Venoms, Viper Venoms.
- Animals, Biological Evolution, Evolution, Molecular, Molecular Sequence Data, Phylogeny, Skin Cream.
Abstract
The molecular origin of waglerin peptides has remained enigmatic despite their industrial application in skin cream products to paralyse facial muscles and thus reduce the incidence of wrinkles. Here we show that these neurotoxic peptides are the result of de novo evolution within the prepro region of the C-type natriuretic peptide gene in Tropidolaemus venoms, at a site distinct from the domain encoding for the natriuretic peptide. It is the same region that yielded the azemiopsin peptides from Azemiops feae, indicative of a close relationship of this toxin gene between these two genera. The precursor region for the molecular evolution is a biodiversity hotspot that has yielded other novel bioactive peptides with novel activities. We detail the diversity of components in this and other species in order to explore what characteristics enable it to be such a biodiscovery treasure trove. The unusual function of Tropidolaemus venoms may have been selected for due to evolutionary pressures brought about by a high likelihood of prey escape.
DOI: 10.1007/s00239-016-9764-6
PubMed: 27864608
Affiliations:
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Here we show that these neurotoxic peptides are the result of de novo evolution within the prepro region of the C-type natriuretic peptide gene in Tropidolaemus venoms, at a site distinct from the domain encoding for the natriuretic peptide. It is the same region that yielded the azemiopsin peptides from Azemiops feae, indicative of a close relationship of this toxin gene between these two genera. The precursor region for the molecular evolution is a biodiversity hotspot that has yielded other novel bioactive peptides with novel activities. We detail the diversity of components in this and other species in order to explore what characteristics enable it to be such a biodiscovery treasure trove. The unusual function of Tropidolaemus venoms may have been selected for due to evolutionary pressures brought about by a high likelihood of prey escape.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>France</li><li>République populaire de Chine</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Debono, Jordan" sort="Debono, Jordan" uniqKey="Debono J" first="Jordan" last="Debono">Jordan Debono</name></noRegion><name sortKey="Fry, Bryan G" sort="Fry, Bryan G" uniqKey="Fry B" first="Bryan G" last="Fry">Bryan G. Fry</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Xie, Bing" sort="Xie, Bing" uniqKey="Xie B" first="Bing" last="Xie">Bing Xie</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Violette, Aude" sort="Violette, Aude" uniqKey="Violette A" first="Aude" last="Violette">Aude Violette</name></noRegion><name sortKey="Fourmy, Rudy" sort="Fourmy, Rudy" uniqKey="Fourmy R" first="Rudy" last="Fourmy">Rudy Fourmy</name></country><country name="France"><noRegion><name sortKey="Jaeger, Marc" sort="Jaeger, Marc" uniqKey="Jaeger M" first="Marc" last="Jaeger">Marc Jaeger</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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